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Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress

Similarly, vitamin E has been demonstrated to reduce radiation damage among patients suffering from head and neck cancer but on the other hand it has been associated with higher risks of recurrence especially among smokers since smoking elevates tissue hypoxia and blood carboxyhemoglobin levels thereby reducing oxygen dependent radiotherapy action (42)

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doi:10.1086/705337

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