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Dendrimers can entrap therapeutic molecules through non-covalent interactions and function as solubilizing agents or stabilizers while providing protected compartments for systemic transport, thereby enhancing drug bioavailability (115)

5-Demethylnobiletin ameliorates isoproterenol-induced cardiac fibrosis and apoptosis by repressing the Sirt1/FOXO3a/NF-kappaB and Wnt/beta-catenin pathways

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however, their clinical translation has been hindered by physicochemical instability, rapid metabolism, and insufficient brain exposure