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Immune cells express VDR, and through binding with VD, they affect gene expression and signaling pathways, thereby regulating the function of immune cells (Di Rosa et al., 2011)

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The broad appeal of these drugs is showcased by the Food and Drug Administrations approval of electrophilic drugs that act by forming covalent bonds against cancer-relevant targets such as BTK 30 , EGFR 31 or KRAS G12C (ref

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