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Conservar a una temperatura no superior a 25C en lugar fresco y seco, lejos de la luz solar
Orlistat and cyclosporine should not be simultaneously co-administered Patients should be strongly encouraged to take a multivitamin supplement that contains fat-soluble vitamins to ensure adequate nutrition because Orlistat has been shown to reduce the absorption of some fat-soluble vitamins and beta-carotene Rare cases of severe liver injury with hepatocellular necrosis or acute hepatic failure have been reported, with some of these cases resulting in liver transplant or death Patients may develop increased levels of urinary oxalate following treatment with Orlistat
These include: a) Aldh1a1, Aldh2, Aldh1b1, Cat, Cyp2e1, Adh3a1 and Gclm single knockouts (KO) b) Aldh1a1 and Aldh3a1 knock-in lines (both have mutated the Cys-302 of the active site) c) Aldh1a1/Aldh1b1, Aldh1b1/Aldh2, Cat/Cyp2e1 and Gclm/Nrf2 double knockouts (DKO) d) Conditional Gclc floxed strain e) Hepatocyte-specific Gclc knockout Funded by NIAAA (R24AA022057) Contact Please send inquiries and requests to: Dr
2011;3:a005678
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