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The SHAPE study, analyzing real-world prescribing data, found: At 3 months: tirzepatide users lost 5.9% of body weight versus 3.6% for semaglutide At 6 months: 10.1% versus 5.8% At 12 months: 15.3% versus 8.3% These are averages from actual patients, not trial participants

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Clinical study personnel were blinded to the randomization procedure until after the trial had ended

Hence, future studies should implement standardized imaging protocols or establish conversion factors to enhance longitudinal comparability