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Description

A peer-reviewed review on arbutin reported that alpha arbutin reduced melanin content in a human skin model to 40% of the control at a dose of 250 g per tissue without causing cell death , and the same review also discussed a study where the total surface area of melasma appearance dropped from 1398.5 mm to 923.4 mm by day 60 with a mean melasma area and severity index reduction of 2.25 1.87 over that period, as described in this review of arbutin research on PubMed Central

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