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On this page: Approaches to Drug Product Expiration Date Extensions Initiated by the Manufacturer Shelf-Life Extension Program Emergency Use Authorities (including stockpiler-initiated) Enforcement Discretion MCM Expiration Dating Extensions Additional Information Approaches to Drug Product Expiration Date Extensions Initiated by the Manufacturer The manufacturer of an approved drug product may extend the expiration date for the drug product based on acceptable data from full, long-term stability studies on at least three pilot or production batches in accordance with a protocol approved in the NDA or ANDA
This heterogeneity in phenotypic rescue across different developmental time points suggests that periods of therapeutic intervention will need to be assessed on a gene-to-gene basis
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In this regard, their use on one-two punch approaches (in which senescence inducers are combined with senolytics) could enhance their effectiveness, as senescent cells are more sensitive to GPX4 inhibition
This is known as a double-blind study
