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Several studies have shown that H 2 S itself activates angiogenesis in cancer, 161,162,163,164 evidence that was used to develop strategies to promote the release of H 2 S and the activation of angiogenesis under certain pathological circumstances, such as wound healing 165,166 and inflammatory diseases

A recent systematic review and meta-analysis of 25 observational studies found proton-pump inhibitor use was associated with a small increased risk of vitamin B 12 deficiency

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