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Tripartite combination of candidate pandemic mitigation agents: vitamin D, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by genomics-guided tracing of SARS-CoV-2 targets in human cells

Furthermore, the endoplasmic Reticulum (ER) Stress by unfolded Protein Response (UPR) crucial role in protein folding and detoxification processes (62)

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While they do not directly restore the lipid lamellae of the stratum corneum, they do support the structural foundation upon which barrier function depends

The single biggest gap between expectation and reality is timing