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Managing Discontinuation: The 20-Week Taper Strategy A significant challenge with GLP-1 RA therapy is the rate of weight regain once the medication is stopped

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Nail matrix melanoma Dermoscopic features of nail matrix melanoma include: Longitudinal brown to black parallel lines with irregular colouration, spacing, or thickness Disruption of parallelism, for example, pigmentation increases in width proximally Brown background Hutchinson sign: pigmentation of nail fold Nail plate fissuring or destruction These features are not entirely reliable and should not be used as a substitute for biopsy if there is any doubt about the origin of longitudinal melanonychia

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