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A recent study found that GLP-1 drugs like Ozempic and Wegovy may significantly reduce blood pressure

In vivo , intraperitoneal administration of the NRF2 activator RTA-408 significantly upregulated NRF2 expression in neurons of SOD1 G93A transgenic mice, which consequently elevated the expression of GSH, SLC7A11, and GPX4, reduced MDA and ROS levels, suppressed neuronal ferroptosis, lipid peroxidation, and mitochondrial injury, and ameliorated weight loss and motor dysfunction in mice (Yang et al., 2023)

The clinical decision on protocol length and maintenance frequency is made at the APRN evaluation based on the individual patients response and goals