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These studies reveal the pivotal roles of transcription factors such as Nrf2, HIF, and REST in regulating ferroptosis during the transition from AKI to CKD, providing directions for the development of novel therapeutic targets

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DB designed and supervised the research program, analyzed data, and wrote the manuscript

In addition, other relevant therapies based on incretins, including GIP receptor (GIP-R) agonists, dual GLP-1R/GIPR agonists, GLP-1R/GIPR/Glucagon receptor (GCGR) triagonists, and oxyntomodulin (OXM), have been shown to improve outcomes of T2DM in a series of preclinical trials (55, 56)