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113 In thyroid-hormone-responsive cell lines, carnitine inhibited the nuclear uptake of thyroid hormones, which suggests that L-carnitine may limit tissue and organ susceptibility to excess thyroid hormone levels, potentially decreasing the signs and symptoms of hyperthyroidism

A deeper exploration of these biomarkers could lead to more comprehensive evaluation of ferroptosis-inducing strategies, such as targeting GPX4 with inhibitors like RSL3 in cancer therapy or modulating TFR1-mediated iron uptake in tumor cells [68, 69] 3.3 Tumour micro environment (TME)-driven oxidative stress and its impact on antioxidant therapy A tumour microenvironment contains multiple components which include cancer cells, stromal cells alongside immune cells and extracellular matrix (ECM) with various signalling molecules [70]

That is not because they do not know

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doi: 10.1371/journal.pone.0041088