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Several randomised control trials have shown a higher rate of gallbladder and biliary disorders in patients using these agents compared with placebo

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BMJ 347:f5934 [DOI] [PMC free article] [PubMed] [Google Scholar] 6.OBrien PE et al (2019) Long-term outcomes after bariatric surgery: a systematic review and meta-analysis of weight loss at 10 or more years for all bariatric procedures and a single-centre review of 20-year outcomes after adjustable gastric banding

More than 30 units means larger injection volumes, which some researchers find uncomfortable or impractical