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After accumulation in certain tissues, they then induce a variety of adverse effects in various body systems, and when symptomatic, they are generally described as causing heavy metal-mediated toxicity

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J Cell Mol Med 24:54085419 Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, Yang W et al (2021) D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2-dependent manner

Subclinical Hypothyroidism Elevated TSH levels characterize subclinical hypothyroidism, while free T4 remains within the normal range

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