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Indeed, ingestion of 1525 g of APAP is fatal in a quarter of cases due to acute liver failure (Larson et al., 2005)

10.1186/s13287-019-1253-6 19 ChenC.WangJ.SunM.LiJ.WangH

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doi:10.1038/emboj.2011.105, PMID: 21478822 Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P (2008) Redox regulation of cell survival

Similarly, solid lipid nanoparticles loaded with curcumin and turmerone were optimized using response surface methodology for topical delivery, resulting in enhanced stability, controlled release, and reduced irritation [149]