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When the pH drops below their isoelectric point, their net charge becomes positive, allowing electrostatic interactions with negatively charged polysaccharides and making them highly appropriate for immobilization applications (285)

That is, it prevents it from breaking down in your gut, allowing it to be absorbed

doi: 10.1038/s41598-021-87257-0, 24

You should maintain a routine until your symptoms clear up, and then follow your doctors specific maintenance regimen if you suffer from conditions that lead to B12 deficiencies or already have a deficiency

No overdosage has been reported with Nascobal Nasal Spray, Nascobal (Cyanocobalamin, USP) Gel for Intranasal Administration or parenteral vitamin B12