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One study on the pain-modulating IceWave patches showed a meaningful reduction in the chronic inflammatory process (of COX-2, PGE-2, PGF-2, IL-1 and lactic acid) as well as changes to neuropeptides Substance P and Vasoactive Intestinal Peptides (VIP) [R]

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S2CID 25534747

GR first, permanova test p = 0.6989)

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