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As primarily secreted proteins, IGFBPs are released into the extracellular space, where they interact with IGF-1 (Oxvig and Conover, 2023)

That is the baseline requirement and the condition under which the labeled expiration date applies

Yet, they face challenges including low biocompatibility, low mechanical strength, and slow response that limit their feasibility

2,1921 A level of less than 150 pg per mL (111 pmol per L) is diagnostic for deficiency

Research indicates that it functions as a natural anti-inflammatory and antioxidant agent, with applications in healthcare, medical products, and cosmetic formulations