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Often referred to as the 'satiety hormone', leptin signals to the brainspecifically the hypothalamuswhen the body has sufficient energy stores, thereby reducing appetite and increasing energy expenditure

Incretinsprincipally glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)are gut hormones that stimulate insulin secretion in response to meals

Elevated levels of adenosine in certain brain regions, such as the cortex and basal forebrain, have been associated with prolonged wakefulness, while lower levels are observed during sleep recovery periods

Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health