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Injections bypass the digestive tract, which makes them more effective for people with absorption issues or severe deficiencies

The SURMOUNT-1 trial showed up to 20.9% body weight reduction with 15 mg tirzepatide over 72 weeks, compared to roughly 15% with semaglutide in the STEP trials

The vitamin is also essential for DNA synthesis and red blood cell formation, meaning deficiency can have wide-ranging effects beyond the nervous system, including fatigue and cognitive difficulties

Time mattersmany payers have 90-day appeal windows