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The gutbrain axis involves bidirectional communication via the vagus nerve, HPA axis, and microbial metabolites, with gut enterochromaffin cells producing approximately 90% of the bodys serotonin (Yano et al., 2015)

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10.1016/j.intimp.2024.113734 19 CuiY.ZhangY.ZhaoX.ShaoL.LiuG.SunC.et al (2021)

These domains play distinct roles in regulating the transcriptional activity of NRF2 [22]