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These could include barrier-enhancing microbiota-derived metabolites or probiotics to restore BBB integrity

This option could be of preference in women with metabolic or cardiovascular conditions that contraindicate the use of estroprogestins [60]

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Transdermal forms of vitamin B 12 are available over the counter, but this route of administration has not been validated clinically in the setting of vitamin B 12 deficiency and should not be relied upon for treatment