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This sets it apart from traditional GLP-1 receptor agonists, which only affect one pathway

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Bioanalysis of GLP-1 Analog Drugs in Clinical Pharmacokinetic (PK) Studies For the bioanalysis of GLP-1 analog drugs in clinical PK samples, like other peptide/protein drugs, two commonly used methods are ligand binding assay (LBA) and liquid chromatography-mass spectrometry (LC-MS/MS)

We hypothesized that prolonged fasting would have a greater effect on reducing gastric volume and retained solid gastric contents than withholding GLP-1 therapy