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Progression to advanced fibrosis and cirrhosis leads to liverrelated morbidity and mortality, while competing CV risk remains high

The primary mechanisms of action include: Enhancing glucose-dependent insulin secretion from pancreatic beta cells, which helps lower blood glucose levels when they are elevated Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production [1] [2] Slowing gastric emptying , which moderates the rate at which nutrients enter the bloodstream Promoting satiety through central nervous system pathways, leading to reduced caloric intake [1] [2] These medications are peptide-based (and one fusion protein) and are temperature sensitive

The initial results of clinical trials have showcased the impressive weight loss benefits of GLP-1 analogues, such as semaglutide (Wegovy), liraglutide (Ozempic), oral semaglutide (Rybelsus), retatrutide, and tirzepatide

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