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Current evidence from large cardiovascular outcome trials provides reassurance that this modest chronotropic effect does not translate into increased cardiovascular risk for most patients

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B12+MIC therapy requires approval from a licensed physician

Common adverse effects include nausea and vomiting, as well as increased hazards of gastroparesis and small bowel obstruction

Criteria similar to a recent Cochrane review were applied to our data, namely applying fixed cutoffs of 80% for either sensitivity or specificity, and testing the outcome for the non-fixed parameter