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Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial

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Acquisition of allelic imbalance and loss of heterozygosity Apparent loss of SNVs and indels can be caused by a number of processes: deletion of one or more copies of an allele including LOH, reversion of mutations, dominance in metastases by sub-clones without mutations, and genetic heterogeneity in antecedent tumours not inherited by later metastases or acquired at the site of origin after dissemination of metastatic cells 29