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Studies have shown that administration of Trp and its partial metabolites alleviated colitis symptoms in UC models of mice, whereas removal of Trp from the diet increased disease susceptibility[105 ]

Delaying intake by just 2 h results in significantly lower glycogen concentrations and reduced performance the following day (145)

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Lee, G., et al., Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1alpha activation

Among all complications, persistent organ failure (lasting more than 48 h) is the most important predictor of adverse outcomes