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In addition to biocompatibility, biodegradation, bioadhesiveness, and biofunctionality of the NDBs, several drawbacks must be addressed, such as low stability, low melting point, high surface tension, structural complexity, and well-known immunological response from organisms (Ige et al., 2012

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However, it does block IL-1-beta surface binding to T cells and inhibits hyperalgesic effects of IL-1-beta in vivo, suggesting alternative signaling mechanisms that researchers continue to investigate