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However, it is known that the placental dysfunction is often gradual and it can occur much earlier than any demonstrable IUGR[188], thus difficulting the resolution of this hypothesis

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Magoffin DA, Weitsman SR: Insulin-like growth factor-I regulation of luteinizing hormone (LH) receptor messenger ribonucleic acid expression and LH-stimulated signal transduction in rat ovarian theca-interstitial cells