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They are characterized by extreme spatiotemporal heterogeneity, as instead of possessing a single unique structure, they exist as dynamic, interconverting ensembles of multiple conformations

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further notes that a restricted maintenance dose of just four injections per year is what is normally allowed, which can leave people physically and mentally unable to contribute to either family or society, and lead to permanent neurological damage

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In fact, any chronic GI disorder can result in low cobalamin levels