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The study included patients with renal insufficiency classified on the basis of creatinine clearance as mild (50 to less than 80 mL/min), moderate (30 to less than 50 mL/min), and severe (less than 30 mL/min), as well as patients with ESRD on hemodialysis

Carefully designed dose-response curves for both individual and combined peptides are essential

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Clinical trials, including the SUSTAIN and STEP programs, have documented that gastrointestinal symptoms occur in a substantial proportion of patients initiating semaglutide therapy