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I confess that I had never heard of NAION until I read the recent JAMA article about its possible association with GLP-1 RA medications

To establish stratified co-culture of STC-1 and NIT-1 cells in 24-well plates using transwell, STC-1 cells were first plated on top of the matrigel and then NIT-1 cells were cultured in 24-well plates

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8-OHdG can be excised from the DNA during repair mechanisms, thus being released in the blood stream and subsequently be excreted in the urine, patients-derived biofluids where it can be detected (Lunec et al., 2002)