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The fatigue with dose increases is often milder than initial treatment fatigue because your body has already adapted to some degree during earlier months

Content Updated: September 13, 2025 Key takeaways Semaglutide is a prescription injection that aids weight loss by affecting hormones that regulate hunger and fullness, mimicking the natural GLP-1

GERD (Acid Reflux) GLP-1 users have a somewhat increased risk of gastroesophageal reflux disease (GERD), a condition in which the stomach acid can flow backward, up into the esophagus

One produces roughly 6% body weight loss in clinical trials

Keep a Food and Symptom Diary Track what you eat and how you feel afterward