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Some substrates irreversibly inhibit P450s via covalent interaction of a metabolically generated reactive intermediate that may react with the P450 apoprotein or heme moiety or even cause the heme to fragment and irreversibly modify the apoprotein

Glutathione plays a protective role in maintaining endothelial function, preventing LDL oxidation, and modulating inflammatory signaling in the vascular wall [2][5]

The current evidence is mainly derived from analyses of circulating and urinary biomarkers, as well as small-scale observational studies

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Several interventions have reversed MPs-induced neurotoxicity by targeting the gut microbiota, supporting a causal role of the MGBA (Yang J.-Z