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In summary, LALPVYN not only scavenges intracellular free radicals, but also enhances endogenous antioxidant defense systems, including antioxidant enzyme defense systems and glutathione systems, thereby reducing H 2 O 2 -induced MDA and free radical production in HepG2 cells, and achieving cell protection

3.3.3 Receptors mediated mitophagy activators Panax notoginseng saponins (PNS), the primary ingredient from Panax notoginseng, exhibits extensive therapeutic effects in cardiovascular diseases (Yang et al., 2016) and diabetes ( via hypoxia-inducible factor-1 (HIF-1)

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Its sequence Ala-Glu-Asp-Gly comprises four residues with no known direct receptor target

Studies suggest that Cl - transport by CFTR is affected by pyocyanin-generated ROS production, which leads to glutathione and ATP depletion