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The mechanisms of excessive ROS production during the CIRI process include: (1) Mitochondrial dysfunction during ischemia reduces electron transport chain efficiency, increasing free radical generation

As demonstrated by studies, selenium supplementation seems to aid insulin sensitivity and the antioxidant state in PCOS women, hence suggesting its potential application in treatment (43) ( Figure 7 )

The clinical symptoms of these diseases manifest as cognitive decline, memory loss, and impairment of limb movement

Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials

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