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Triptans act on the serotonin receptors (5-HT1B) in the blood vessels of the brain, constricting them and inhibiting the release of neuropeptides.[ref] Genetic studies show a link between migraine susceptibility and a type of genetic variant known as a variable number tandem repeat in a serotonin transporter gene.[ref] Using PET scans on people who had been migraine-free for at least 48 hours, researchers can study the 5-HT1B (serotonin) receptor in the brain

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For BPC-157 , the deepest non-musculoskeletal literature is gastrointestinal: cytoprotection of the stomach lining, ulcer healing, and effects on fistula and anastomosis healing in rodents, tied mechanistically to the nitric-oxide system

doi: 10.3390/antiox13070868 81 ZhuXZhangCFengSHeRZhangS

Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance