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This rapid explosion of oxidative stress quickly consumes the host's amino acids and antioxidant reserves, leading to a profound depletion of intracellular glutathione

88,89 At this time, polyethylene glycol is not Food and Drug Administration-approved nor guideline-recommended (AASLD 2014) for the treatment of HE, though it is mentioned as possible alternative therapy pending further study

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10.3389/fphys.2013.00103 Front