RMT, on the other hand, relies on the binding of NPs to specific transmembrane receptors abundantly expressed on BBB endothelial cells, such as the transferrin receptor (TfR), insulin receptor (IR), low-density lipoprotein receptor-related protein-1 (LRP1), or nicotinic acetylcholine receptor (nAChR) [137]
doi: 10.1016/J.SCP.2020.100218 185 van den HeuvelD
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4.2 Ferroptosis and rheumatoid arthritis Rheumatoid arthritis (RA) is the typical autoimmune disease that primarily targets the synovial membrane of the joints, resulting in the synovium transforming into a hyperplastic and invasive tissue that destroys cartilage and bone (128)