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Research by Ershov et al

This deletion places US11 under immediate-early promoter control while enhancing replication efficiency in tumor cells for HSV-1 strains lacking ICP34.5, suggesting promising applications for oncolytic virotherapy ( In summary, when ICP47 is deleted from its genome context, it can serve as an effective tool to reduce immune evasion in immunodeficient environments and tumor cells

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The activation of VIP receptors stimulates the adenylyl cyclase to generate cytosolic cAMP that activate the cystic fibrosis transmembrane conductance regulator (CFTR), resulting in secretion of Cl into the lumen