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4 Restless Leg Syndrome (RLS) A neurological disorder known as restless leg syndrome, or RLS, causes uncomfortable feelings in the legs that are frequently characterized as tingling, hurting, or crawling. These sensations create an irresistible urge to move, especially during periods of rest or inactivity, such as bedtime

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Next, serine hydroxymethyltransferase cleaves -hydroxy-- N -trimethyllysine into - N -trimethylaminobutyraldehyde and glycine, using pyridoxal 5-phosphate as a cofactor

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The expression of thyroid hormone receptors in human bone