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Consequently, despite the clear message of landmark trials such as the Diabetes Control and Complications Trial and the UK Prospective Diabetes Study regarding the need for excellent glycemic control, diabetes remains the leading cause of blindness, renal failure, and amputations

Figure 1 Besides CD8+ NKG2D+ T cells and IFN-, some inflammatory cells and cytokines also play a significant role in the immune pathogenesis of alopecia areata, such as dendritic cells, CD4 + T cells, NK T cells, mast cells and eosinophils, and other cytokines such as IL-2, CXCLs, and TNF-

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doi:10.1016/S1470-2045(15)70076-8 Weber, J.S., Hodi, F.S., Wolchok, J.D., Topalian, S.L., Schadendorf, D., Larkin, J.,