glp-1 appetite suppression for Weight Loss and Diabetes Intrinsic limitations of the pharmacological

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Develop an individualized exercise plan that includes low-impact activities, balance exercises, and flexibility training

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to activate the AMPK/SIRT1 pathway, ameliorating lipid accumulation in palmitate-induced hepatocytes and suppressing hepatic steatosis in HFD-fed mice, thus improving NAFLD (Pyun et al., 2021)