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In toxin-induced rodent models of PD (MPTP, 6-OHDA, rotenone, LPS), exendin-4 (142145), liraglutide (146, 147), lixisenatide (146), and semaglutide (57, 148) reduced dopaminergic neuron loss, preserved striatal terminals, and improved motor performance, in association with stabilization of mitochondria, reduced oxidative stress, and reduced inflammation

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This creates a cycle of renewal that helps keep the intestinal lining strong