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Subsequently, the medium was replaced with OPTI-MEM supplemented with 5% FBS and 1% sodium pyruvate

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In primary prevention in very high-risk patients with FH and in patients with FH and ASCVD, the recommended treatment goal is reduction of LDL-C concentration by 50% from baseline and a target LDL-C concentration 200 mg/dl (2.3 mmol/l)

Plotting of the 1/v (M min 1 ) axis intercept against inhibitor concentration yielded a K i value of 57.6 M for RB