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Conversely, selenium deficiency reduces GPX4 activity, increasing cellular susceptibility to ferroptosis and exacerbating intestinal mucosal damage induced by microbial metabolites such as DCA

HGH (somatropin) is FDA-approved for specific conditions including pediatric and adult growth hormone deficiency

Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency

(4) Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H

The statements regarding these products have not been evaluated by the FDA