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154 The release of IL-1 amplifies the inflammatory cascade by promoting cytokine production, particularly by inducing IL-6 expression in monocytes and macrophages, thereby sustaining inflammation

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In vitro and animal studies suggests that GSH depletion plays an important role in OS-mediated neuronal death and is implicated in neuronal loss in several neurodegenerative diseases, such as Parkinsons disease [16], AD [17], and amyotrophic lateral sclerosis [12], making it a potential therapeutic target to prevent or reduce neurodegeneration

95% CI 12.03, 2.32)