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Funding This present study was supported by the Foundation of Hubei Educational Committee (grant no

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In females, L2-Cmu mAb treatment led to a slight, albeit significant reduction in red blood cells (RBCs), hemoglobin (Hb), hematocrit (Hct), white blood cells (WBCs), lymphocytes (Supplementary Table 2), and serum phosphorus (Supplementary Table 3), though most values, with the exception of WBCs, remained within the normal range, and were less severely affected than previously reported with Ganitumab in young CD1 mice 26

However, a dose-dependent insulinotropic and glucagonostatic response is preserved in response to exogenous GLP-1 treatment and 6-week subcutaneous GLP-1 infusion was shown to improve HbA1c levels by 1.3% [18]

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