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Its small size and copper-binding affinity underpin its bioactivity, distinguishing it from larger proteins or synthetic peptides

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Following the treatment course, the MASI score of the included patients was increased from 41.7% to 85%, however, the melasma severity scale (MSS) was decreased from moderate (score 2) to mild (score 1) during the treatment course (Kusumawardani et al., 2019)

Meiners, F., Secci, R., Sueto, S., Fuellen, G

At that point, tissue-level GHK-Cu has likely returned to baseline, and the cumulative signaling advantage of the loading phase is largely lost